Signs, Symptoms, and Complications of Thrombotic Thrombocytopenic Purpura

Blood clots, a low platelet count, and damaged red blood cells cause the signs and symptoms of thrombotic thrombocytopenic purpura (TTP).

The signs and symptoms include:

  • Purplish bruises on the skin or mucous membranes (such as in the mouth). These bruises, called purpura, are caused by bleeding under the skin.
  • Pinpoint-sized red or purple dots on the skin. These dots, called petechiae, often are found in groups and may look like a rash. Bleeding under the skin causes petechiae.
  • Paleness or jaundice (a yellowish color of the skin or whites of the eyes).
  • Fatigue (feeling very tired and weak).
  • Fever.
  • A fast heart rate or shortness of breath.
  • Headache, speech changes, confusion, coma, stroke, or seizure.
  • A low amount of urine, or protein or blood in the urine.

If you've had TTP and have any of these signs or symptoms, you may be having a relapse (flareup). Ask your doctor when to call him or her or seek emergency care.


Source: National Heart, Lung, and Blood Institute, National Institutes of Health.